CANCER CONTROL AND PREVENTION IN EUROPE: THE CONTRIBUTION OF THE EUROPEAN JOURNAL OF CANCER PREVENTION (EJCP)
Jaak Ph Janssens & Carlo La Vecchia
After continuous increases in cancer rates until the late 1980’s or early 1990’s, the last two decades have seen leveling and a subsequent decline of cancer mortality in Europe, and rates in 2010 in most European countries are 15% to 20% lower that the peak ones registered in the late 1980’s (Malvezzi et al., 2011).
The European Journal of Cancer Prevention (EJCP) was funded at the peak of the cancer epidemic in Europe, with the major aim to contribute to its control. It was clear at that time that the key measure for cancer control was prevention, including essentially stopping smoking, but also reduction of alcohol, changes in diet and elimination of occupational carcinogens. Over the last few years, the EJCP has monitored and provided relevant impact to all the major areas of cancer prevention and control. This was not only realized by bringing scientists together in a forum that allowed strong feeds to a broad field of research areas. Governments, health care workers, and individuals at particular risks found the way to the Journal and based major life style change initiatives on the contents of many papers.
The issues of interest include monitoring of trends in cancer incidence and mortality across Europe, defining individual cancer risk (Goossens and De Greve, 2010) and quantify the recent leveling and declines in colorectal (Parkin et al., 2009; van Steenbergen et al., 2009; Coviello et al., 2010; Crocetti et al., 2010), as well as lung, breast and female genital tract cancers and several other neoplasms (Faure et al., 2009; Kellert et al., 2009; Lacour et al., 2010; Marcos-Gragera et al., 2010; Martin-Lopez et al., 2010; La Vecchia, 2011). Similar trends have been observed, and were monitored by the EJCP in other areas of the world as well (Diaz Mdel et al., 2009; Lorenzo-Luaces Alvarez et al., 2009; Rozen et al., 2009; Andreatta et al., 2010; Chatenoud et al., 2010; Harirchi et al., 2010; Niclis et al., 2010).
A key attention has been given to tobacco, which remains the major preventable cause of cancer and cancer death in Europe. In most European countries, tobacco control has improved over the last two decades, although there have been substantial delays between quantification of tobacco-related cancer risk and adoption of effective measures on a population scale, and substantial differences in tobacco control remain across various European countries and within countries across socio-economic strata of the population. These differences demonstrate once more and even today the powerful negative impact of tobacco on general health. Monitoring tobacco control deserves therefore continuing attention (Ferketich et al., 2009a; Ferketich et al., 2009b; Hilgert et al., 2009; Polesel et al., 2009; Spadea et al., 2009; Verla-Tebit et al., 2009; Hertrampf et al., 2010).
Alcohol is another well recognized cause of cancer. Alcohol consumption has substantially decreased over the last three decades in France, Italy, and other countries of southern Europe, but has increased and remains exceedingly high in Central and Eastern Europe. Thus, attention on the role of alcohol in cancer causation across Europe, and on interventions on alcohol reduction has to be maintained, particularly in central and eastern Europe (Ishiguro et al., 2009; Lagiou et al., 2009; Pelucchi and La Vecchia, 2009; Goldstein et al., 2010; Hjartaker et al., 2010). Focus needs to be held on the relationship of alcohol consumption and socio-economic situations, in particular with regard to a rapid changing economical atmosphere.
Since its start, the EJCP has devoted considerable interest in aspects of diet and nutrition, including measures of body mass, metabolic disorders and physical activity, on cancer risk. After two decades of accumulating research on diet, nutrition and cancer, quantification of their role on cancer risk remains largely open to discussion. Hence additional attention is requested for better focusing cancer prevention interventions on a public health scale and in particular on children. The available data spans from basic research in rodents, to epidemiology, to population interventions. All these areas have been covered by the EJCP over recent years, and remain among its priorities in the foreseeable future (Almquist et al., 2009; Baumeister et al., 2009; Boffetta et al., 2009; Carnide et al., 2009; Engeset et al., 2009; Inoue et al., 2009; Iranshahi et al., 2009; Kountouri et al., 2009; Mann et al., 2009; Mathew et al., 2009; Panneerselvam et al., 2009; Papadopoulos et al., 2009; Paschke et al., 2009; Rhee et al., 2009; Sangeetha et al., 2009; Solanas et al., 2009; Tavani et al., 2009; Wang et al., 2009; Alexander et al., 2010; Alfonso et al., 2010; Ataee et al., 2010; Deandrea et al., 2010; Fagherazzi et al., 2010; Fares et al., 2010; Hellmann et al., 2010; Jedrychowski et al., 2010; Leem et al., 2010; Liebens et al., 2010; Maskarinec et al., 2010; Mu et al., 2010; Olsen et al., 2010; Peng et al., 2010; Rabstein et al., 2010; Roswall et al., 2010; Sonoda et al., 2010; Tanwar et al., 2010; Williams, 2010).
Cancer screening, surveillance and early diagnosis have also substantially contributed to the control of colorectal, cervical, breast cancers, and perhaps skin melanoma and prostate cancer. Monitoring all these activities on a population scale has been, and will remain, a key focus for cancer control in Europe, and an area of priority interest for the EJCP (Agorastos et al., 2009; Alves et al., 2009; Cornelis et al., 2009; Dimitrakaki et al., 2009; Hartman et al., 2009; Kapp et al., 2009; Kovacs et al., 2009; Luo et al., 2009; Nielsen et al., 2009; Oh et al., 2009; Peuvrel et al., 2009; Quereux et al., 2009; Sperati et al., 2009; Vutuc et al., 2009; Botelho et al., 2010; Boulet et al., 2010; Branstrom et al., 2010; D’Ambrosio et al., 2010; de Maleissye et al., 2010; Fortes et al., 2010; Goldshtein et al., 2010; Harries et al., 2010; Kaur and Sanyal, 2010; Loehberg et al., 2010; Panagoulopoulou et al., 2010; Quereux et al., 2010; Vermeer and Van den Muijsenbergh, 2010; Zografos et al., 2010).
Finally, chemoprevention has a relevant role for reducing risk of selected cancer sites, particularly of the colorectum and of hormone-related sites. This field (again, from cells to rodents, to clinical trials, to populations) has substantially developed over the last two decades, and continuum attention has been given to it by the EJCP (Gatenby et al., 2009; La Vecchia and Bosetti, 2009; Wang et al., 2009; Yuan et al., 2009; Zucchetto et al., 2009; Bojkova et al., 2010; Bonifazi et al., 2010; Bosetti et al., 2010; Choi et al., 2010; Tian et al., 2010).
Over the next years, the EJCP will further focus on these key areas of cancer control and prevention, with the aim of monitoring and contributing to a further reduction in cancer mortality in Europe, by at least 15% from now to 2025 (La Vecchia, 2011).
Agorastos T, Lambropoulos AF, Sotiriadis A, Mikos T, Togaridou E, Emmanouilides CJ (2009). Prevalence and distribution of high-risk human papillomavirus in Greece. Eur J Cancer Prev18: 504-509.
Alexander DD, Miller AJ, Cushing CA, Lowe KA (2010). Processed meat and colorectal cancer: a quantitative review of prospective epidemiologic studies. Eur J Cancer Prev19: 328-341.
Alfonso HS, Reid A, de Klerk NH, Olsen N, Mina R, Ambrosini GL, et al. (2010). Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia. Eur J Cancer Prev19: 355-359.
Almquist M, Anagnostaki L, Bondeson L, Bondeson AG, Borgquist S, Landberg G, et al. (2009). Serum calcium and tumour aggressiveness in breast cancer: a prospective study of 7847 women. Eur J Cancer Prev18: 354-360.
Alves C, Alves L, Lunet N (2009). Prevalence and determinants of cervical cytology use in an urban sample of Portuguese women. Eur J Cancer Prev18: 482-488.
Andreatta MM, Navarro A, Munoz SE, Aballay L, Eynard AR (2010). Dietary patterns and food groups are linked to the risk of urinary tract tumors in Argentina. Eur J Cancer Prev19: 478-484.
Ataee R, Ajdary S, Zarrindast M, Rezayat M, Shokrgozar MA, Ataee A (2010). Y25130 hydrochloride, a selective 5HT3 receptor antagonist has potent antimitogenic and apoptotic effect on HT29 colorectal cancer cell line. Eur J Cancer Prev19: 138-143.
Baumeister P, Reiter M, Kleinsasser N, Matthias C, Harreus U (2009). Epigallocatechin-3-gallate reduces DNA damage induced by benzo[a]pyrene diol epoxide and cigarette smoke condensate in human mucosa tissue cultures. Eur J Cancer Prev18: 230-235.
Boffetta P, Nordenvall C, Nyren O, Ye W (2009). A prospective study of gout and cancer. Eur J Cancer Prev18: 127-132.
Bojkova B, Garajova M, Kajo K, Pec M, Kubatka P, Kassayova M, et al. (2010). Pioglitazone in chemically induced mammary carcinogenesis in rats. Eur J Cancer Prev19: 379-384.
Bonifazi M, Gallus S, Bosetti C, Polesel J, Serraino D, Talamini R, et al. (2010). Aspirin use and pancreatic cancer risk. Eur J Cancer Prev19: 352-354.
Bosetti C, Bravi F, Talamini R, Montella M, Negri E, La Vecchia C (2010). Aspirin and risk of endometrial cancer: a case-control study from Italy. Eur J Cancer Prev19: 401-403.
Botelho F, Pina F, Lunet N (2010). VEGF and prostatic cancer: a systematic review. Eur J Cancer Prev19: 385-392.
Boulet GA, Horvath CA, Depuydt CE, Bogers JJ (2010). Biomarkers in cervical screening: quantitative reverse transcriptase PCR analysis of P16INK4a expression. Eur J Cancer Prev19: 35-41.
Branstrom R, Chang YM, Kasparian N, Affleck P, Tibben A, Aspinwall LG, et al. (2010). Melanoma risk factors, perceived threat and intentional tanning: an international online survey. Eur J Cancer Prev19: 216-226.
Carnide N, Kreiger N, Cotterchio M (2009). Association between frequency and intensity of recreational physical activity and epithelial ovarian cancer risk by age period. Eur J Cancer Prev18: 322-330.
Chatenoud L, Bertuccio P, Bosetti C, Levi F, Curado MP, Malvezzi M, et al. (2010). Trends in cancer mortality in Brazil, 1980-2004. Eur J Cancer Prev19: 79-86.
Choi KH, Kim HK, Kim JH, Choi ES, Shin JA, Lee SO, et al. (2010). The p38 MAPK pathway is critical for 5,5′-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells. Eur J Cancer Prev19: 153-159.
Cornelis A, Verjans M, Van den Bosch T, Wouters K, Van Robaeys J, Janssens JP (2009). Efficacy and safety of direct and frontal macrobiopsies in breast cancer. Eur J Cancer Prev18: 280-284.
Coviello E, Caputi G, Martinelli D, Germinario CA, Prato R (2010). Mortality trends for primary liver cancer in Puglia, Italy. Eur J Cancer Prev19: 417-423.
Crocetti E, Buzzoni C, Zappa M (2010). Colorectal cancer incidence rates have decreased in central Italy. Eur J Cancer Prev19: 424-425.
D’Ambrosio GG, Campo S, Cancian M, Pecchioli S, Mazzaglia G (2010). Opportunistic prostate-specific antigen screening in Italy: 6 years of monitoring from the Italian general practice database. Eur J Cancer Prev19: 413-416.
de Maleissye MF, Beauchet A, Aegerter P, Saiag P, Mahe E (2010). Parents’ attitudes related to melanocytic nevus count in children. Eur J Cancer Prev19: 472-477.
Deandrea S, Foschi R, Galeone C, La Vecchia C, Negri E, Hu J (2010). Is temperature an effect modifier of the association between green tea intake and gastric cancer risk? Eur J Cancer Prev19: 18-22.
Diaz Mdel P, Osella AR, Aballay LR, Munoz SE, Lantieri MJ, Butinof M, et al. (2009). Cancer incidence pattern in Cordoba, Argentina. Eur J Cancer Prev18: 259-266.
Dimitrakaki C, Boulamatsis D, Mariolis A, Kontodimopoulos N, Niakas D, Tountas Y (2009). Use of cancer screening services in Greece and associated social factors: results from the nation-wide Hellas Health I survey. Eur J Cancer Prev18: 248-257.
Engeset D, Dyachenko A, Ciampi A, Lund E (2009). Dietary patterns and risk of cancer of various sites in the Norwegian European Prospective Investigation into Cancer and Nutrition cohort: the Norwegian Women and Cancer study. Eur J Cancer Prev18: 69-75.
Fagherazzi G, Fabre A, Boutron-Ruault MC, Clavel-Chapelon F (2010). Serum cholesterol level, use of a cholesterol-lowering drug, and breast cancer: results from the prospective E3N cohort. Eur J Cancer Prev19: 120-125.
Fares F, Azzam N, Appel B, Fares B, Stein A (2010). The potential efficacy of 3,3′-diindolylmethane in prevention of prostate cancer development. Eur J Cancer Prev19: 199-203.
Faure C, Mollie A, Bellec S, Guyot-Goubin A, Clavel J, Hemon D (2009). Geographical variations in the incidence of childhood acute leukaemia in France over the period 1990-2004. Eur J Cancer Prev18: 267-279.
Ferketich AK, Gallus S, Colombo P, Apolone G, Rossi S, Zuccaro P, et al. (2009a). Use of pharmacotherapy while attempting cessation among Italian smokers. Eur J Cancer Prev18: 90-92.
Ferketich AK, Gallus S, Colombo P, Pacifici R, Zuccaro P, La Vecchia C (2009b). Hardcore smoking among Italian men and women. Eur J Cancer Prev18: 100-105.
Fortes C, Mastroeni S, Bakos L, Antonelli G, Alessandroni L, Pilla MA, et al. (2010). Identifying individuals at high risk of melanoma: a simple tool. Eur J Cancer Prev19: 393-400.
Gatenby PA, Ramus JR, Caygill CP, Winslet MC, Watson A (2009). Aspirin is not chemoprotective for Barrett’s adenocarcinoma of the oesophagus in multicentre cohort. Eur J Cancer Prev18: 381-384.
Goldshtein I, Neeman U, Chodick G, Shalev V (2010). Variations in hemoglobin before colorectal cancer diagnosis. Eur J Cancer Prev19: 342-344.
Goldstein BY, Chang SC, Hashibe M, La Vecchia C, Zhang ZF (2010). Alcohol consumption and cancers of the oral cavity and pharynx from 1988 to 2009: an update. Eur J Cancer Prev19: 431-465.
Goossens MC, De Greve J (2010). Individual cancer risk as a function of current age and risk profile. Eur J Cancer Prev19: 485-495.
Harirchi I, Karbakhsh M, Montazeri A, Ebrahimi M, Jarvandi S, Zamani N, et al. (2010). Decreasing trend of tumor size and downstaging in breast cancer in Iran: results of a 15-year study. Eur J Cancer Prev19: 126-130.
Harries R, Lawson S, Bruckers L (2010). Assessment of microcalcifications with limited number of high-precision macrobiopsies. Eur J Cancer Prev19: 374-378.
Hartman E, van den Muijsenbergh ME, Haneveld RW (2009). Breast cancer screening participation among Turks and Moroccans in the Netherlands: exploring reasons for nonattendance. Eur J Cancer Prev18: 349-353.
Hellmann SS, Thygesen LC, Tolstrup JS, Gronbaek M (2010). Modifiable risk factors and survival in women diagnosed with primary breast cancer: results from a prospective cohort study. Eur J Cancer Prev19: 366-373.
Hertrampf K, Wiltfang J, Koller M, Klosa K, Wenz HJ (2010). Dentists’ perspectives on oral cancer: a survey in Northern Germany and a comparison with international data. Eur J Cancer Prev19: 144-152.
Hilgert E, Bergmann C, Fichtner A, Gires O, Issing W (2009). Tobacco abuse relates to significantly reduced survival of patients with oropharyngeal carcinomas. Eur J Cancer Prev18: 120-126.
Hjartaker A, Meo MS, Weiderpass E (2010). Alcohol and gynecological cancers: an overview. Eur J Cancer Prev19: 1-10.
Inoue M, Noda M, Kurahashi N, Iwasaki M, Sasazuki S, Iso H, et al. (2009). Impact of metabolic factors on subsequent cancer risk: results from a large-scale population-based cohort study in Japan. Eur J Cancer Prev18: 240-247.
Iranshahi M, Sahebkar A, Takasaki M, Konoshima T, Tokuda H (2009). Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo. Eur J Cancer Prev18: 412-415.
Ishiguro S, Inoue M, Tanaka Y, Mizokami M, Iwasaki M, Tsugane S (2009). Serum aminotransferase level and the risk of hepatocellular carcinoma: a population-based cohort study in Japan. Eur J Cancer Prev18: 26-32.
Jedrychowski W, Maugeri U, Popiela T, Kulig J, Sochacka-Tatara E, Pac A, et al. (2010). Case-control study on beneficial effect of regular consumption of apples on colorectal cancer risk in a population with relatively low intake of fruits and vegetables. Eur J Cancer Prev19: 42-47.
Kapp U, Otto F, Senn HJ (2009). Fifth international conference on cancer prevention, St. Gallen, 6-8 March 2008. Eur J Cancer Prev18: 93-94.
Kaur J, Sanyal SN (2010). Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac. Eur J Cancer Prev19: 319-327.
Kellert IM, Botterweck AA, Huveneers JA, Dirx MJ (2009). Trends in incidence of and mortality from uterine and ovarian cancer in Mid and South Limburg, The Netherlands, 1986-2003. Eur J Cancer Prev18: 85-89.
Kountouri AM, Kaliora AC, Koumbi L, Andrikopoulos NK (2009). In-vitro gastric cancer prevention by a polyphenol-rich extract from olives through induction of apoptosis. Eur J Cancer Prev18: 33-39.
Kovacs K, Varnai AD, Bollmann M, Bankfalvi A, Szendy M, Speich N, et al. (2009). A 7.5-year prospective study of longer than 18 months type-specific human papillomavirus persistence in a routine cytology-based cervical screening population of about 31,000 women in West Germany. Eur J Cancer Prev18: 307-315.
La Vecchia C (2011). The future of cancer in Europe. Eur J Cancer Prev20: 253-254.
La Vecchia C, Bosetti C (2009). Oral contraceptives and neoplasms other than breast and female genital tract. Eur J Cancer Prev18: 407-411.
Lacour B, Guyot-Goubin A, Guissou S, Bellec S, Desandes E, Clavel J (2010). Incidence of childhood cancer in France: National Children Cancer Registries, 2000-2004. Eur J Cancer Prev19: 173-181.
Lagiou P, Georgila C, Minaki P, Ahrens W, Pohlabeln H, Benhamou S, et al. (2009). Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection. Eur J Cancer Prev18: 76-84.
Leem DH, Choi KH, Han HS, Kim JH, Shin JA, Choi ES, et al. (2010). KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression. Eur J Cancer Prev19: 23-30.
Liebens F, Aimont M, Beauraing F, Carly B, Cusumano P, Rozenberg S (2010). What information do public organizations provide to Belgian women on primary prevention of breast cancer? Eur J Cancer Prev19: 68-70.
Loehberg CR, Heusinger K, Jud SM, Haeberle L, Hein A, Rauh C, et al. (2010). Assessment of mammographic density before and after first full-term pregnancy. Eur J Cancer Prev19: 405-412.
Lorenzo-Luaces Alvarez P, Guerra-Yi ME, Faes C, Galan Alvarez Y, Molenberghs G (2009). Spatial analysis of breast and cervical cancer incidence in small geographical areas in Cuba, 1999-2003. Eur J Cancer Prev18: 395-403.
Luo P, He E, Eriksson S, Zhou J, Hu G, Zhang J, et al. (2009). Thymidine kinase activity in serum of renal cell carcinoma patients is a useful prognostic marker. Eur J Cancer Prev18: 220-224.
Malvezzi M, Arfe A, Bertuccio P, Levi F, La Vecchia C, Negri E (2011). European cancer mortality predictions for the year 2011. Ann Oncol22: 947-956.
Mann CD, Neal CP, Garcea G, Manson MM, Dennison AR, Berry DP (2009). Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis. Eur J Cancer Prev18: 13-25.
Marcos-Gragera R, Cervantes-Amat M, Vicente ML, de Sanjose S, Guallar E, Godoy C, et al. (2010). Population-based incidence of childhood leukaemias and lymphomas in Spain (1993-2002). Eur J Cancer Prev19: 247-255.
Martin-Lopez R, Hernandez-Barrera V, De Andres AL, Garrido PC, De Miguel AG, Garcia RJ (2010). Breast and cervical cancer screening in Spain and predictors of adherence. Eur J Cancer Prev19: 239-245.
Maskarinec G, Woolcott C, Steude JS, Franke AA, Cooney RV (2010). The relation of leptin and adiponectin with breast density among premenopausal women. Eur J Cancer Prev19: 55-60.
Mathew A, Gajalakshmi V, Rajan B, Kanimozhi VC, Brennan P, Binukumar BP, et al. (2009). Physical activity levels among urban and rural women in south India and the risk of breast cancer: a case-control study. Eur J Cancer Prev18: 368-376.
Mu R, Lu N, Wang J, Yin Y, Ding Y, Zhang X, et al. (2010). An oxidative analogue of gambogic acid-induced apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its anticancer activity in vitro. Eur J Cancer Prev19: 61-67.
Niclis C, Del Pilar Diaz M, La Vecchia C (2010). Breast cancer mortality trends and patterns in Cordoba, Argentina in the period 1986-2006. Eur J Cancer Prev19: 94-99.
Nielsen A, Munk C, Liaw KL, Kjaer SK (2009). Awareness of human papillomavirus in 23 000 Danish men from the general male population. Eur J Cancer Prev18: 236-239.
Oh JK, Franceschi S, Kim BK, Kim JY, Ju YH, Hong EK, et al. (2009). Prevalence of human papillomavirus and Chlamydia trachomatis infection among women attending cervical cancer screening in the Republic of Korea. Eur J Cancer Prev18: 56-61.
Olsen A, Landberg R, Aman P, Kamal-Eldin A, Christensen J, Johnsen NF, et al. (2010). Plasma levels of alkylresorcinols and incidence of endometrial cancer. Eur J Cancer Prev19: 73-77.
Panagoulopoulou E, Alegakis A, Abu Mourad T, Sanidas E, Makrigiannakis A, Philalithis A (2010). The role of general practitioners in promoting cervical cancer screening: a field survey in a rural area of Crete, Greece. Eur J Cancer Prev19: 160-166.
Panneerselvam J, Aranganathan S, Nalini N (2009). Inhibitory effect of bread crust antioxidant pronyl-lysine on two different categories of colonic premalignant lesions induced by 1,2-dimethylhydrazine. Eur J Cancer Prev18: 291-302.
Papadopoulos FC, Pantziaras I, Lagiou P, Brandt L, Ekselius L, Ekbom A (2009). Age at onset of anorexia nervosa and breast cancer risk. Eur J Cancer Prev18: 207-211.
Parkin DM, Olsen AH, Sasieni P (2009). The potential for prevention of colorectal cancer in the UK. Eur J Cancer Prev18: 179-190.
Paschke D, Abarzua S, Schlichting A, Richter DU, Leinweber P, Briese V (2009). Inhibitory effects of bark extracts from Ulmus laevis on endometrial carcinoma: an in-vitro study. Eur J Cancer Prev18: 162-168.
Pelucchi C, La Vecchia C (2009). Alcohol, coffee, and bladder cancer risk: a review of epidemiological studies. Eur J Cancer Prev18: 62-68.
Peng JH, Zhu JD, Mi MT, Li FJ, Cai L, Dong JZ, et al. (2010). Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis. Eur J Cancer Prev19: 110-119.
Peuvrel L, Quereux G, Jumbou O, Sassolas B, Lequeux Y, Dreno B (2009). Impact of a campaign to train general practitioners in screening for melanoma. Eur J Cancer Prev18: 225-229.
Polesel J, Serraino D, Zucchetto A, Lucenteforte E, Dal Maso L, Levi F, et al. (2009). Cigarette smoking and endometrial cancer risk: the modifying effect of obesity. Eur J Cancer Prev18: 476-481.
Quereux G, Nguyen JM, Volteau C, Dreno B (2009). Prospective trial on a school-based skin cancer prevention project. Eur J Cancer Prev18: 133-144.
Quereux G, Nguyen JM, Volteau C, Lequeux Y, Dreno B (2010). Creation and test of a questionnaire for self-assessment of melanoma risk factors. Eur J Cancer Prev19: 48-54.
Rabstein S, Bruning T, Harth V, Fischer HP, Haas S, Weiss T, et al. (2010). N-acetyltransferase 2, exposure to aromatic and heterocyclic amines, and receptor-defined breast cancer. Eur J Cancer Prev19: 100-109.
Rhee HV, Coebergh JW, Vries ED (2009). Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiological studies. Eur J Cancer Prev18: 458-475.
Roswall N, Olsen A, Christensen J, Dragsted LO, Overvad K, Tjonneland A (2010). Micronutrient intake and breast cancer characteristics among postmenopausal women. Eur J Cancer Prev19: 360-365.
Rozen P, Liphshitz I, Barchana M (2009). The changing epidemiology of upper gastrointestinal cancers in Israel: clinical and screening implications. Eur J Cancer Prev18: 191-198.
Sangeetha N, Felix AJ, Nalini N (2009). Silibinin modulates biotransforming microbial enzymes and prevents 1,2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer. Eur J Cancer Prev18: 385-394.
Solanas M, Moral R, Garcia G, Grau L, Vela E, Escrich R, et al. (2009). Differential expression of H19 and vitamin D3 upregulated protein 1 as a mechanism of the modulatory effects of high virgin olive oil and high corn oil diets on experimental mammary tumours. Eur J Cancer Prev18: 153-161.
Sonoda T, Suzuki H, Mori M, Tsukamoto T, Yokomizo A, Naito S, et al. (2010). Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men. Eur J Cancer Prev19: 131-137.
Spadea T, D’Errico A, Demaria M, Faggiano F, Pasian S, Zanetti R, et al. (2009). Educational inequalities in cancer incidence in Turin, Italy. Eur J Cancer Prev18: 169-178.
Sperati A, Pannozzo F, Giorgi Rossi P, Baiocchi D, Barca A, Borgia P (2009). Validating regional Hospital Information System data through comparison with a local cancer register to identify interval cancers of a breast screening program. Eur J Cancer Prev18: 212-215.
Tanwar L, Vaish V, Sanyal SN (2010). Chemopreventive role of etoricoxib (MK-0663) in experimental colon cancer: induction of mitochondrial proapoptotic factors. Eur J Cancer Prev19: 280-287.
Tavani A, Bravi F, Dal Maso L, Zucchetto A, Bosetti C, Pelucchi C, et al. (2009). Physical activity and risk of endometrial cancer: an Italian case-control study. Eur J Cancer Prev18: 303-306.
Tian W, Zhao Y, Liu S, Li X (2010). Meta-analysis on the relationship between nonsteroidal anti-inflammatory drug use and gastric cancer. Eur J Cancer Prev19: 288-298.
van Steenbergen LN, Lemmens VE, Louwman MJ, Straathof JW, Coebergh JW (2009). Increasing incidence and decreasing mortality of colorectal cancer due to marked cohort effects in southern Netherlands. Eur J Cancer Prev18: 145-152.
Verla-Tebit E, Lilla C, Hoffmeister M, Brenner H, Chang-Claude J (2009). Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from Germany. Eur J Cancer Prev18: 9-12.
Vermeer B, Van den Muijsenbergh ME (2010). The attendance of migrant women at the national breast cancer screening in the Netherlands 1997-2008. Eur J Cancer Prev19: 195-198.
Vutuc C, Waldhoer T, Lunglmayr G, Hoeltl W, Haidinger G (2009). PSA testing in Austria: induced morbidity and saved mortality. Eur J Cancer Prev18: 377-380.
Wang Q, Zhao W, Wu G (2009). Valsartan inhibits NPC cell line CNE-2 proliferation and invasion and promotes its sensitivity to radiation. Eur J Cancer Prev18: 510-517.
Williams GP (2010). The role of oestrogen in the pathogenesis of obesity, type 2 diabetes, breast cancer and prostate disease. Eur J Cancer Prev19: 256-271.
Yuan S, Shi C, Han W, Ling R, Li N, Wang T (2009). Effective anti-tumor responses induced by recombinant bacillus Calmette-Guerin vaccines based on different tandem repeats of MUC1 and GM-CSF. Eur J Cancer Prev18: 416-423.
Zografos GC, Sergentanis TN, Zagouri F, Papadimitriou CA, Domeyer P, Kontogianni PN, et al. (2010). Breast self-examination and adherence to mammographic follow-up: an intriguing diptych after benign breast biopsy. Eur J Cancer Prev19: 71-72.
Zucchetto A, Serraino D, Polesel J, Negri E, De Paoli A, Dal Maso L, et al. (2009). Hormone-related factors and gynecological conditions in relation to endometrial cancer risk. Eur J Cancer Prev18: 316-321.